Anticancer drug development guide : preclinical screening, clinical trials, and approval /
Experienced cancer researchers from pharmaceutical companies, government laboratories, and academia comprehensively review and describe in Dr. Beverly Teicher's Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval the arduous process of cancer drug discovery a...
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| Format: | eBook |
| Language: | English |
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Totowa, N.J. :
Humana Press,
[1997]
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| Series: | Cancer drug discovery and development.
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| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- pt. 1. In vitro methods
- High-volume screening
- The NCI in vitro anticancer drug discovery screen: concept, implementation, and operation, 1985-1995
- Human tumor screening
- pt. 2. In vivo methods
- Murine L1210 and P388 leukemias
- In vivo methods for screening and preclinical testing: use of rodent solid tumors for drug discovery
- Human tumor xenograft models in NCI drug development
- Fertile seed and rich soil: the development of clinically relevant models of human cancer by surgical orthotopic implantation of intact tissue
- Preclinical models for high-dose therapy
- Models for minimal residual tumor
- Spontaneously occurring tumors in companion animals as models for drug development
- pt. 3. Clinical testing
- Working with the National Cancer Institute
- Phase I trial design and methodology
- Phase II clinical trials in oncology
- Drug development in Europe
- The phase III cancer clinical trial
- FDA role in cancer drug development and requirements for approval.