AIDS clinical trials /

Bibliographic Details
Other Authors:	Finkelstein, Dianne M., Schoenfeld, David A.
Format:	Book
Language:	English
Published:	New York : Wiley-Liss, [1995]
Subjects:	Acquired Immunodeficiency Syndrome > drug therapy. Clinical Trials as Topic > methods. Research Design.

Table of Contents:

Introduction
The natural history of the HIV infection: Implications for clinical trials
The new drug evaluation process: FDA perspective
The new drug evaluation process: Industry perspective
Protocol development
Data issues in AIDS clinical trials
Current methods and future trends in the design and analysis of phase I and phase I/II clinical trials in AIDS
Selection of endpoints for assessment of treatment efficacy in an AIDS trial
The uses of CD4 lymphocyte count to evaluate therapy for HIV disease
Sample size calculations for failure time data
The design and analysis of equivalence trials
Interim monitoring of clinical trials
Behavioral science and the design and conduct of randomized AIDS trials
Compliance in AIDS clinical trials.
Quality-of-life considerations in AIDS clinical trials
Issues in analysis of AIDS clinical trials
Issues in the testing of drug combinations
Issues in the conduct of clinical trials for HIV-infected children.
Clinical trials to reduce the risk of maternal-infant transmission of HIV infection
Obstetrical and gynecological issues in AIDS clinical trials
Prophylactic HIV vaccine trials
Large simple trials of HIV therapies
Economic analysis and AIDS clinical research
Use of observational data for evaluating AIDS therapies
Use of cohort studies for evaluating AIDS therapies.