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|b P963 2006
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|a The process of new drug discovery and development /
|c edited by Charles G. Smith, James T. O'Donnell.
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| 250 |
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|a Second edition.
|
| 264 |
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1 |
|a New York :
|b Informa Healthcare,
|c [2006]
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| 264 |
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4 |
|c ©2006
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| 300 |
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|a 668 pages :
|b illustrations ;
|c 27 cm.
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|a text
|2 rdacontent
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| 337 |
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|a unmediated
|2 rdamedia
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| 338 |
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|a volume
|2 rdacarrier
|b nc
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| 500 |
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|a Revised edition of: The process of new drug discovery and development / Charles G. Smith. c1992.
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| 504 |
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|a Includes bibliographical references and index.
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| 505 |
0 |
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|a Overview of the current process of new drug discovery and development -- Integrated drug product development : from lead candidate selection to life-cycle management -- The impact of combinatorial chemistry on drug discovery -- High-throughput screening : enabling and influencing the process of drug discovery -- Pharmacological and pharmaceutical profiling : new trends -- Cell-based analysis of drug response using moving optical gradient fields -- Patient-derived primary cells in high-throughput differential antitumor screens : let the patients be the guide -- The evolving role of the caco-2 cell model to estimate intestinal absorption potential and elucidate transport mechanisms -- The promise of metabonomics in drug discovery -- Pharmacogenetics and pharmacogenomics in drug development and regulatory decision-making : report of the first FDA-PWG-PhRMA-druSafe workshop -- Drugs from molecular targets for CNS and neurodegenerative diseases -- Safety pharmacology -- Nonclinical drug safety assessment -- Preclinical genotoxicity testing : past, present and future -- The need for animals in biomedical research -- Defining the actual research approach to the new drug substance -- Pharmacokinetics : pharmacodynamics in new drug development -- Pharmaceutics and compounding issues in new drug development and marketing -- Late stage and process development activities -- Contract research organizations : role and function in new drug development -- The front lines of clinical research : the industry -- Horizons for cancer chemotherapy (and nonchemotherapy) -- Human immunodeficiency virus/acquired immune deficiency syndrome : clinical testing challenges -- Common technical document : the changing face of the new drug application -- Electronic publishing -- The important role of pharmacists in a complex risk-management system : managing the risks from medical product use by focusing on patient education, monitoring, and adverse event reporting -- Liability, litigation, and lessons in new drug development -- Problems in the nondrug marketplace -- Patents and new product development in the pharmaceutical and biotechnology industries -- The pharmaceutical revolution : drug discovery and development -- The discovery of Rituxan -- Funding the birth of a drug : lessons from the sell side -- Innovations for the drug development pathway : what is needed now -- Managing R&D uncertainty and maximizing the commercial potential of pharmaceutical compounds using the dynamic modeling framework
|
| 650 |
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|a Drugs
|x Research
|x History.
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| 650 |
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|a Drugs
|x Design
|x History.
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| 650 |
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2 |
|a Drug Design.
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| 650 |
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2 |
|a Drug Evaluation, Preclinical.
|
| 650 |
|
2 |
|a Drug Evaluation.
|
| 700 |
1 |
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|a Smith, Charles G.
|q (Charles Giles)
|
| 700 |
1 |
|
|a O'Donnell, James,
|c Pharm. D.
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|b Rellis Campus
|c Joint Library Facility
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|h National Library of Medicine classification
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