The process of new drug discovery and development /

The process of new drug discovery and development /

Bibliographic Details
Other Authors: Smith, Charles G. (Charles Giles), O'Donnell, James, Pharm. D.
Format: Book
Language:English
Published: New York : Informa Healthcare, [2006]
Edition:Second edition.
Subjects:
Drugs > Research > History.
Drugs > Design > History.
Drug Design.
Drug Evaluation, Preclinical.
Drug Evaluation.
Table of Contents:
  • Overview of the current process of new drug discovery and development
  • Integrated drug product development : from lead candidate selection to life-cycle management
  • The impact of combinatorial chemistry on drug discovery
  • High-throughput screening : enabling and influencing the process of drug discovery
  • Pharmacological and pharmaceutical profiling : new trends
  • Cell-based analysis of drug response using moving optical gradient fields
  • Patient-derived primary cells in high-throughput differential antitumor screens : let the patients be the guide
  • The evolving role of the caco-2 cell model to estimate intestinal absorption potential and elucidate transport mechanisms
  • The promise of metabonomics in drug discovery
  • Pharmacogenetics and pharmacogenomics in drug development and regulatory decision-making : report of the first FDA-PWG-PhRMA-druSafe workshop
  • Drugs from molecular targets for CNS and neurodegenerative diseases
  • Safety pharmacology
  • Nonclinical drug safety assessment
  • Preclinical genotoxicity testing : past, present and future
  • The need for animals in biomedical research
  • Defining the actual research approach to the new drug substance
  • Pharmacokinetics : pharmacodynamics in new drug development
  • Pharmaceutics and compounding issues in new drug development and marketing
  • Late stage and process development activities
  • Contract research organizations : role and function in new drug development
  • The front lines of clinical research : the industry
  • Horizons for cancer chemotherapy (and nonchemotherapy)
  • Human immunodeficiency virus/acquired immune deficiency syndrome : clinical testing challenges
  • Common technical document : the changing face of the new drug application
  • Electronic publishing
  • The important role of pharmacists in a complex risk-management system : managing the risks from medical product use by focusing on patient education, monitoring, and adverse event reporting
  • Liability, litigation, and lessons in new drug development
  • Problems in the nondrug marketplace
  • Patents and new product development in the pharmaceutical and biotechnology industries
  • The pharmaceutical revolution : drug discovery and development
  • The discovery of Rituxan
  • Funding the birth of a drug : lessons from the sell side
  • Innovations for the drug development pathway : what is needed now
  • Managing R&D uncertainty and maximizing the commercial potential of pharmaceutical compounds using the dynamic modeling framework